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. 2019 Aug 13;19:634–646. doi: 10.1016/j.isci.2019.08.018

Figure 1.

Figure 1

Dysfunction of GABAARs in the Hyperekplexic Mutant Mice

(A) Trace records, average frequency, and amplitude of GABAergic sIPSCs in brainstem hypoglossal nucleus slices from WT, GlyRα1R271Q, and GlyRα1S267Q mutant mice.

(B) Trace records and average amplitude of GABAergic eIPSCs in brainstem hypoglossal nucleus slices from WT and GlyRα1R271Q mutant mice.

(C) Trace records and average values of GABA maximal current induced by puffing 1 mM GABA in brainstem hypoglossal nucleus slices from WT and GlyRα1S267Q mutant mice.

(D) Trace records, average frequency, and amplitude of GABAergic mIPSCs in brainstem hypoglossal nucleus slices from WT and GlyR α1S267Q mutant mice.

(E) Trace records and average values of BSTC in brainstem hypoglossal nucleus slices from WT and GlyRα1S267Q mutant mice.

All digits within the columns represent numbers of cells measured from at least three mice. Data are represented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 based on unpaired t tests; ns, not significant (p > 0.05).