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. 2019 Aug 10;19:623–633. doi: 10.1016/j.isci.2019.08.017

Figure 2.

Figure 2

Intracellular Application of Anti-p-p65 (s311) or Extracellular Application of PDTC Preferably Reduces TTX-S Na+ Currents over TTX-R Ones within Minutes

(A–C) The effects of intracellular anti-p-p65 (10 μg/mL) on total (A), TTX-S (B) and TTX-R (C) Na+ currents. The raw traces were recorded immediately on onset (black) and 18 min (red) after recordings. n = 6 in each group. ∗p < 0.05, ∗∗∗p < 0.001 compared with the corresponding IgG group. (D–F) The effects of extracellular NF-κB inhibitor PDTC (10 nM) on total (D), TTX-S (E) and TTX-R (F) Na+ currents. The raw traces were recorded immediately on onset (black) and 18 min (red) after recordings. n = 6 in each group. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 compared with the corresponding vehicle group.

(G and H) The histograms show the inhibitory rates of anti-p-p65 (G) and PDTC (H) on total, TTX-S, and TTX-R currents at 18 min after recordings. ∗p < 0.05, ∗∗p < 0.01 compared with total currents; ##p < 0.01, ###p < 0.001 compared with TTX-S currents. A-F, two-way repeated measures ANOVA followed by Bonferroni's multiple comparisons test; G and H, one-way ANOVA followed by Holm-Sidak's multiple comparisons test. Data expressed as mean ± SD.