Kcnq1 Expression and Its Impacts on Osteosarcoma Cell Migration and Invasion (n = 47)
(A and B) Kcnq1 expression in osteosarcoma and normal tissues. (C and D) Kcnq1-positive expression in osteosarcoma and normal tissues (400×). (E) The expression of Kcnq1 in osteosarcoma cell lines. MG-63 cells were treated with oe-Kcnq1 or sh-Kcnq1, with oe-NC and sh-NC as the controls. (F and G) The migration situation of MG-63 cells in each group (200×). (H and I) The invasion situation of MG-63 cells in each group (200×). *p < 0.05 versus adjacent tissues or hFOB1.19 cells or the blank group. The measurement data were expressed as mean ± SD, and the enumeration data were presented by number of cases or percentage. Comparison between the osteosarcoma and normal tissues was analyzed by paired t test, and comparison between the other two groups was processed with independent t test. Comparisons among multiple groups were analyzed by one-way ANOVA. The analysis of comparison of enumeration data was performed with chi-square analysis. The experiment was repeated 3 times. NC, negative control.