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A Proposed Model of the Three miRNAs’ Mode of Action
miR140-5p, miR-140-3p, and miR-146a regulated expression of key components of inflammation, autophagy, and other degradation pathways. A proposed model of how this might promote cartilage integrity and protection under adverse inflammatory conditions is shown. Arrows and green boxes represent positive regulation, while the perpendicular lines and red boxes represent inhibition.
