Table 3.
Altered Proteins upon miR-146a Overexpression
| Protein | Protein Name | Fold Change | Biological Process | Predicted Targets |
|---|---|---|---|---|
| Upregulated by miR-146a | ||||
| CUL1 | Cullin-1 | 7.0 | ubiquitination and degredation, lysosomal | |
| NEUR1 | Sialidase-1 | 6.0 | ||
| PPIF | peptidyl-prolyl cis-trans isomerase F, mitochondrial | 3.8 | mitochondrial metabolism, phospholipid metabolism | |
| PCAT1 | lysophosphatidylcholine acyltransferase | 2.6 | ||
| PCOC1 | procollagen C-endopeptidase enhancer 1 | 2.0 | enzymatic cleavage of type I procollagen | |
| GIT2 | ARF GTPase-activating protein GIT2 | 2.3 | GTPase-activating protein (GAP) activity | |
| Downregulated by miR-146a | ||||
| TAP1 | antigen peptide transporter 1 | −INFa | inflammation, innate/adaptive immune responses | |
| SEP10 | Septin-10 | −7.0 | ||
| STAT2 | signal transducer and activator of transcription 2 | −4.4 | STAT2b,c | |
| RIPK2 | receptor-interacting serine/threonine-protein kinase 2 | −INFa | ||
| ABCF1 | ATP-binding cassette sub-family F member 1 | −3.3 | ||
| SHPK | sedoheptulokinase OS | −INFa | SHPKb,c | |
| QORX | quinone oxidoreductase PIG3 | −4.5 | oxidative stress/ROS | |
| MT1E | Metallothionein-1E | −3.0 | ||
| LAMP1 | lysosome-associated membrane glycoprotein 1 (CD107a) | −3.0 | lysosomal, chaperone/ proteinfolding | |
| DNJA1 | DnaJ homolog subfamily A member 1 | −2.8 | ||
| HYOU1 | hypoxia upregulated protein 1 | −2.3 | HYOU1c | |
| NDUA2 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | −INFa | mitochondrial respiratory, metabolism | |
| TOM34 | mitochondrial import receptor subunit | −5.0 | ||
| F120B | constitutive coactivator of peroxisome proliferator-activated receptor gamma | −INFa | F120Bc,d | |
| PNPO | pyridoxine-5′-phosphate oxidase | −2.7 | ||
| HCFC1 | host cell factor 1 | −6.0 | transcription and cell cycle control, histone, chromatin factors, and nuclear proteins | |
| SP16H | FACT complex subunit SPT16 | −6.0 | ||
| PELO | protein pelota homolog | −INFa | PELOd | |
| DDX21 | nucleolar RNA helicase 2 | −2.2 | ||
| AAAS | Aladin | −2.0 | ||
| GTPB1 | GTP-binding protein 1 | −INFa | degradation of target mRNA, circadian mRNA stability | |
| MED18 | mediator of RNA polymerase II transcription subunit 18 | −INFa | coactivator of transcripton of all RNA pol II genes | |
| TM109 | transmembrane protein 109 | −INFa | DNA-damage response/DNA repair | |
| TRIPC | E3 ubiquitin-protein ligase | −INFa | ||
| ADPPT | L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | −INFa | post-translational modification | |
| ATAD1 | ATPase family AAA domain-containing protein 1 | −INFa | regulation of cell surface expression of AMPA receptors | |
| FMNL3 | formin-like protein 3 | −INFa | cytoskeletal organization and adherens juctions | FMNL3b |
| GEPH | Gephyrin | −INFa | GEPHc | |
| VEZA | Vezatin | −INF3a | ||
| RAGP1 | ran GTPase-activating protein 1 | −2.2 | trafficking, transport from the cytoplasm to the nucleus | |
| CRK | adaptor molecule crk (p38) | −2.2 | proto-oncogene, several signaling pathways | CRKe |
INF, infinity.
a
Only detected in control transfected cells
b
Predicted targets according to miRwalk: prediction based on 3′UTR
c
Predicted targets according to miRwalk: prediction based on coding region
d
Predicted targets according to miRwalk: prediction based on 5′UTR
e
Predicted targets according to miRDB