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. 2019 Aug 23;10:1977. doi: 10.3389/fmicb.2019.01977

TABLE 3.

Treatment success with individual antibiotics.

Antibiotic Total (n = 244) M. abscessus subsp. abscessus pulmonary disease (n = 185) M. abscessus subsp. massiliense pulmonary disease (n = 59)



Adjusted ORa 95% CIa,b P-value Adjusted OR 95% CI P-value Adjusted OR 95% CI P-value
Clarithromycin 0.588 0.290–1.194 0.142 0.425 0.191–0.945 0.036 1.460 0.214–9.962 0.699
Azithromycin 1.558 0.844–2.877 0.156 2.339 1.141–4.794 0.020 0.295 0.061–1.418 0.128
Amikacin 3.275 1.221–8.788 0.018 5.911 1.247–28.012 0.025 15.023 1.294–174.400 0.030
Imipenem 2.078 1.151–3.753 0.015 2.050 1.018–4.126 0.044 1.357 0.280–6.575 0.705
Meropenem 1.218 0.390–3.806 0.735 1.787 0.486–6.574 0.382 0.341 0.026–4.487 0.413
Cefoxitin 1.121 0.659–1.908 0.672 1.253 0.656–2.394 0.495 0.610 0.133–2.795 0.524
Linezolidc 2.231 1.078–4.616 0.031 2.875 1.221–6.772 0.016 1.286 0.189–8.746 0.797
Tigecycline 2.040 1.079–3.857 0.028 1.971 0.931–4.173 0.076 2.614 0.291–23.514 0.391
Doxycycline 0.599 0.260–1.380 0.229 0.628 0.222–1.772 0.379 0.408 0.053–3.147 0.390
Minocycline 0.992 0.399–2.467 0.986 0.691 0.206–2.315 0.549 1.312 0.116–14.876 0.827
Moxifloxacinc 0.695 0.372–1.300 0.255 0.866 0.393–1.908 0.720 1.495 0.303–7.388 0.622
Levofloxacinc 0.474 0.193–1.162 0.103 0.453 0.142–1.445 0.181 0.242 0.032–1.857 0.172
Ciprofloxacin 1.026 0.372–2.831 0.960 1.155 0.330–4.039 0.822 0 0 0

aOR, odds ratio; CI, confidence interval. bAdjusted for age, sex, body mass index, and radiographic findings. cAdministered orally and/or intravenously.