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. 2019 Aug 26;11(8):452–463. doi: 10.4252/wjsc.v11.i8.452

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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Schematic representation of the fate of injury/ischemia-induced multipotent stem cells and injury/ischemia-induced neural stem/progenitor cells following ischemic stroke. Under ischemic conditions following stroke, brain pericytes, which constitute the neurovascular unit together with endothelial cells and neural lineage cells, may convert into induced multipotent stem cells (iSCs) by acquiring stemness. iSCs may generate induced neural stem/progenitor cells, which have the potential to differentiate into various neural lineage cells, including neurons, astrocytes, and oligodendrocytes. NG2: Neuronal/glial 2; iSCs: Injury/ischemia-induced multipotent stem cells; PDGFRβ: Platelet-derived growth factor receptor beta; iNSPCs: Injury/ischemia-induced neural stem/progenitor cells.