Table 3.
Chronic myeloid leukemia and acute myeloid leukemia stem cell markers for detection and selective targeting
| Target | CD | CML LSC | AML LSC | Normal HSC | Normal progenitor | Ref. |
| IL-2Rα | CD25 | + | + | - | +/- | [59,69] |
| DPP4 | CD26 | + | - | - | - | [16] |
| Siglec-3 | CD33 | + | + | + | + | [98] |
| SCARB3 | CD36 | + | + | +/- | + | [99] |
| Pgp-1 | CD44 | + | + | + | + | [38] |
| IAP | CD47 | + | + | + | + | [70] |
| Campath-1 | CD52 | + | + | + | + | [100] |
| C1qR1 | CD93 | + | + | +/- | +/- | [101] |
| Tactile | CD96 | - | + | - | - | [66] |
| MIC2 | CD99 | - | + | + | + | [102] |
| SCFR | CD117 | + | + | +/- | +/- | [64] |
| IL-3Rα | CD123 | + | + | +/- | +/- | [68] |
| CLL-1 | - | +/- | + | +/- | + | [67] |
| TIM-3 | - | - | + | +/- | +/- | [71] |
| IL-1RAP | - | + | + | - | + | [60,103] |
CML LSC: Chronic myeloid leukemia stem cells; AML LSC: Acute myeloid leukemia stem cell; HSC: Hematopoietic stem cell; IL-2Rα: Interleukin-2 receptor alpha; DPP4: Dipeptidyl peptidase 4; Siglec-3: Sialic acid-binding immunoglobulin-type lectin-3; SCARB3: Mast/stem cell growth factor receptor; IL-3Rα: Interleukin receptor subunit α; CLL-1: C-type lectin-like molecule-1; TIM-3: T-cell immunoglobulin mucin-3; IL-1RAP: Interleukin-1 receptor accessory protein.