FIGURE 5.

SC51089 significantly inhibited MG63 proliferation in vivo. A) Tumor growth curves in nude mice with MG63 xenograft tumors. The curves of tumor volume were generated every three days for 21 days. B) The weight of excised tumors was measured at the end of experiment. C) PKC activity. D) TUNEL and DAPI staining. All bar/line graphs represent the mean ± SD (n = 6). **p vs. DMSO-treated control (Con). SC51089 treatment decreased PKC activity, reduced tumor weight, and inhibited the growth of MG63 cells in vivo. TUNEL staining revealed that the positive area was lower in the tumor xenograft samples from SC51089 group compared to DMSO-treated control group. PKC: Protein kinase C.