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. 2019 Jun 29;17:791–803. doi: 10.1016/j.omtn.2019.06.018

Figure 3.

Figure 3

LINC01093 Targets ICAM-1 and Binds to FOXP3

(A) Location of LINC01093 in hepatic tissue of mice examined by FISH assay (400×; scale bar, 25 μm). (B) Binding of the FOXP3 and ICAM-1 promoter region predicted by the JASPAR website (http://jaspar.genereg.net/). (C) Binding of FOXP3 and LINC01093 determined by RIP assay. *p < 0.05 versus the IgG. (D) Binding of FOXP3 and ICAM-1 detected by ChIP assay. *p < 0.05 versus IgG; #p < 0.05 versus the NC group. (E) Luciferase activity of ICAM-1-WT and ICAM-1-Mut after transfection; *p < 0.05 versus the NC group. (F) Expression of FOXP3 and ICAM-1 after FOXP3 silencing examined by qRT-PCR. *p < 0.05 versus the NC group. ICAM-1, intercellular cell adhesion molecule-1; FOXP3, forkhead box P3; ChIP, chromatin immunoprecipitation; IgG, immunoglobulin G; NC, negative control.