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. 2019 Jul 19;13(8):8749–8759. doi: 10.1021/acsnano.9b01484

Figure 4.

Figure 4

Decreased liver and improved heart transduction by PPD3/Ad5 complexes in vivo. (a) Fluorescence imaging of the whole mice liver. (b) Immunohistochemical analysis of liver tissue (10× magnification). The cell nucleus was stained by hematoxylin indicated in blue; EGFP was stained by antibodies and DAB (3,3′-diaminobenzidine) as depicted by yellow color. (c) Western blot of EGFP expression in heart, liver, spleen, and lung. (d) Quantification of relative EGFP expression in different organs based on Western blot. All data for PPD3/Ad5 are normalized to the corresponding EGFP expression with naked Ad5 (n = 3). ∗ represents p-value ≤ 0.05, ∗∗ represents p-value ≤ 0.01.