Table 2.

Mean statistics from linear regressions performed to determine substitution profiles

	slope (substitutability)	y-Intercept (initial intensity)	slope 95% CI	Model R²	slope F test (p values)

0 mg/mL
e-Liquid	0	0	0	0	0
Snus	6.13	9.30	−0.33 to 12.6	0.75	9.13 (0.06)
Dip^*	8.46^†	7.58^†	4.66 to 12.3	0.94	50 (<0.01)^*
Nicotine gum	1.63	2.96	−2.06 to 5.33	0.40	1.97 (0.25)
Nicotine lozenge	1.09	1.29	−1.94 to 4.13	0.31	1.32 (0.33)
6 mg/mL
e-Liquid^*	27.44^†	26.3^†	11.4 to 33.1	0.92	32.5 (0.01)^*
Snus	−0.15	2.34	−5.17 to 4.86	0.01	0.01 (0.93)
Dip	−0.48	0.45	−3.41 to 2.45	0.08	0.27 (0.64)
Nicotine gum	−0.80	2.22	−1.57 to −0.02	0.78	5.32 (0.10)
Nicotine lozenge	−0.26	1.26	−1.26 to 0.74	0.19	0.69 (0.46)
12 mg/mL
e-Liquid^*	39.56^†	50.1^†	12.3 to 67.6	0.91	31.1 (0.01)^*
Snus	1.78	3.19	−3.32 to 6.88	0.29	1.24 (0.35)
Dip	0.36	0.24	−0.06 to 0.78	0.71	7.47 (0.07)
Nicotine gum	1.58	3.62	−0.37 to 3.53	0.69	6.69 (0.08)
Nicotine lozenge	0.26	0.50	−2.27 to 2.79	0.03	0.10 (0.76)
24 mg/mL
e-Liquid^*	68.05^†	58.1^†	34.5 to 108.2	0.90	26.3 (0.01)^*
Snus	2.10	3.29	−3.81 to 8.01	0.30	1.28 (0.34)
Dip	−0.05	−0.00	−0.15 to 0.04	0.51	3.14 (0.17)
Nicotine gum	−0.38	0.49	−1.31 to 0.54	0.37	1.74 (0.28)
Nicotine lozenge	−0.44	0.57	−2.17 to 1.29	0.18	0.66 (0.48)

Purchasing is expressed as mg of nicotine purchased for each product.

Indicates that a particular alternate product was a significant substitute for cigarettes at a particular e-liquid strength.

^†

Indicates that the mean slope at a given strength was significantly >0.