Table 2.

OR of a given domain versus other domains including 95% CIs and p values by logistic regression of domain of truncating CDH1 variant and clinical phenotype

Colorectal cancer
Domain	Estimate	2.5%	97.5%	P value
PRE-PRO	6.20	1.79	21.477	0.004
EC 1 and 2	NA	NA	NA	NA
EC 3, 4 and 5	0.872	0.252	3.021	0.8287
IC	1.622	0.445	5.91	0.4632
Linker	0.351	0.073	1.681	0.1902
Breast cancer
PRE-PRO	2.545	0.793	8.171	0.1164
EC 1 and 2	0.685	0.222	2.115	0.5104
EC 3,4 and 5	2.038	0.775	5.36	0.1488
IC	0.821	0.277	2.437	0.7223
Linker	0.346	0.12	0.993	0.0493
Affected family members at young age*
PRE-PRO	1.444	0.292	7.136	0.6518
EC 1 and 2	NA	NA	NA	NA
EC 3, 4 and 5	0.683	0.209	2.226	0.5269
IC	0.195	0.059	0.641	0.0071
Linker	2.333	0.486	11.213	0.2901

^*Gastric cancer at <40 years or lobular breast cancer <50 years.

EC, extracellular; IC, intracellular; NA, too few counts to calculate OR.