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. 2019 Aug 23;10:1890. doi: 10.3389/fimmu.2019.01890

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Copyright © 2019 DeWolfe, Aid, McGann, Ghofrani, Geiger, Helzer, Malik, Kleiboeker, Jost and Tan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Complete separation of IRP+ and IRP– groups indicate contributions from both clinical and immune factors aside from those used to define IRP. PLS-DA plot of IRP+ and IRP– patients using the collected immune data except those that were used to determine IRP (CMV status, CD4 and CD8, and CD8+ senescent (28CD–/CD57+) cells. Each dot on the plot represents a subject, where blue represents IRP+ samples and orange represents IRP– samples. Confidence ellipses for each group were plotted to highlight the strength of the discrimination (confidence level set to 95%). Groups centroids were represented in the center of each group with circles.