Figure 4.
Schematic representation of microglial drug targets discussed in this review. This simplified schematic does not contain all signal transduction molecules known to be involved in the described signaling cascades but focuses on the microglial drug targets discussed in this review indicated by lighting bolts and antibody symbol. IDO, indolamine-2,3-dioxygenase; IL-1β, interleukin 1 beta; IL-18, interleukin 18; KCa3.1, intermediate-conductance calcium-activated potassium channel 3.1; KYN, kynurenine; AA, anthranilic acid; 3-HK, 3-hydroxykynurenine; KATs, kynurenine aminotransferases; KMO, kynurenine 3-monooxygenase (kynurenine 3-hydroxylase); NLRP3, nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain–containing inflammasome complex 3; P2X7, ionotropic P2 receptor 7; TIRAP, TIR domain–containing adaptor protein; MyD88, myeloid differentiation primary response protein 88; TDO, tryptophan-2,3-dioxygenase; TRP, tryptophan. Figure created with Biorender.com