Table 1.

Kynurenine metabolite profile from patients with Alzheimer’s Disease.

Biosample	Metabolite	Effect	Reference
Serum	Trpt	Decreased No Change	Widner et al., 1999; Widner et al., 2000 Schwarz et al., 2013; Oxenkrug et al., 2017
	KYN	Increased No Change	Widner et al., 1999; Widner et al., 2000; Atukeren et al., 2018 Oxenkrug et al., 2017
	AA	Decreased	Oxenkrug et al., 2017
	XA	ND
	KYNA	No Change	Schwarz et al., 2013; Oxenkrug et al., 2017
	3-HK	Increased	Schwarz et al., 2013; Oxenkrug et al., 2017
	Quin	No Change	Schwarz et al., 2013
Plasma	Trpt	Decreased	Greilberger et al., 2010; Giil et al., 2017
	KYN	No Change	Greilberger et al., 2010
	AA	Increased	Chouraki et al., 2017
	XA	Decreased	Giil et al., 2017
	KYNA	Decreased	Heyes et al., 1992; Hartai et al., 2007; Gulaj et al., 2010
	3-HK	Increased	Gulaj et al., 2010
	Quin	Increased Decreased	Gulaj et al., 2010 Giil et al., 2017
CSF	Trpt	Decreased	Tohgi et al., 1992; Muguruma et al., 2018
	KYN	Decreased	Tohgi et al., 1992; Tohgi et al., 1995; Muguruma et al., 2018
	AA	Decreased	Muguruma et al., 2018
	XA	ND
	KYNA	No Change Decreased	Wennström et al., 2014 Heyes et al., 1992; Hartai et al., 2007; Gulaj et al., 2010
	3-HK	Decreased	Tohgi et al., 1992; Muguruma et al., 2018
	Quin	No Change	Mourdian et al., 1989; Heyes et al., 1992
Brain (post mortem)	KYN	No Change (regional)	Baran et al., 1999
	AA	ND
	XA	ND
	KYNA	No Change Increase (caudate/putamen)	Beal et al., 1992 Baran et al., 1999
	3-HK	No Change (regional)	Baran et al., 1999
	Quin	No Change (regional) Increased (plaques/tangles)	Moroni et al., 1986; Mourdian et al., 1989; Sofic et al., 1989; Pearson and Reynolds, 1992; Guillemin et al., 2005; Wu et al., 2013