Table 2. Optimized model parameters.
oxCOX parameters | Unit | Initial value |
Range | |
---|---|---|---|---|
oxCOX signal | Oxidized cytochrome-c-oxidase assessed by NIRS | |||
CuA,o,n | Normal concentration of oxidized CuA | mM | 0.066 | 0.046–0.085 |
Volmit | Fraction of brain tissue volume that is mitochondria | - | 0.067 | 0.054–0.080 |
klk2 | Constant controlling depending of leak rate Llkon Δp | mV−1 | 0.038 | 0.030–0.456 |
Δpn | Normal value of Δp (proton-motive force) | mV−1 | 168.611 | 118.028–219.194 |
NADn/NADHn | Normal NAD+/NADH ratio | - | 9 | 0.1–20 |
k1,n | Forward reaction rate for CuAreduction at normal Δp/NADH | s−1 | 8.3 | 5.810–10.790 |
ck1 | Parameter controlling sensitivity of k1to Δp | mV−1 | 0.01 | 0.008–0.012 |
Tmax,0 | Maximal muscular tension under normal regulatory stimulus | mmHg cm | 2.11 | 1.477–2.743 |
vCO2,n | Normal filtered carbon dioxide partial pressure | mmHg | 40 | 28–52 |
ϕ | Oxygen concentration at half-maximal saturation | mM | 0.036 | 0.029–0.043 |
rm | Vessel radius at which muscular tension is maximal | cm | 0.027 | 0.022–0.032 |
kunc | Parameter simulating effect of uncouplers to the system | - | 1 | 0.8–1.2 |
COXtis | Concentration of COX in tissue | mM | 0.006 | 0.004–0.007 |
Llk0 | Constant controlling the depending of the leak rate Llk on Δp | mM s−1 | 0.004 | 0.003–0.006 |
ptot | Total protons moved out of mitochondrial matrix | - | 20 | 18–20 |
Kσ | Parameter controlling sensitivity of σe to vessel radius | - | 10 | 7–13 |
CVinh | Control parameter representing action of CCO inhibitors | - | 1 | 0.8–1.2 |
vu,n | Normal filtered demand | - | 1 | 0.7–1.3 |
h0 | Thickness of blood vessel walls at which radius is r0 | cm | 0.003 | 0.002–0.004 |
Pic | Intracranial pressure | mmHg | 9.5 | 7–11 |
TOI parameters | Unit | Initial value |
Range | |
TOI signal | Tissue oxygenation index assessed by NIRS | |||
Tmax,0 | Maximal muscular tension under normal regulatory stimulus | mmHg cm | 2.109 | 1.477–2.743 |
D02 | Diffusion rate for oxygen between capillaries and mitochondria | s−1 | 0.842 | 0.589–1.094 |
rt | Radius in the muscular tension relationship | cm | 0.018 | 0.014–0.022 |
ϕ | Oxygen concentration at half-maximal saturation | mM | 0.036 | 0.029–0.043 |
vCO2,n | Normal filtered carbon dioxide partial pressure | mmHg | 40 | 28–52 |
rn | Normal effective blood vessel radius | cm | 0.019 | 0.015–0.022 |
Kσ | Parameter controlling sensitivity of σe to vessel radius | - | 10 | 7–13 |
Volv | Relative venous blood volume | - | 0.75 | 0.525–0.975 |
klk2 | Constant controlling depending of leak rate Llkon Δp | mV−1 | 0.038 | 0.030–0.456 |
vO2,n | Normal filtered capillary oxygen concentration | mM | 0.064 | 0.045–0.084 |
kaut | Overall functioning of autoregulatory response | - | 1 | 0–1 |
NADn/NADHn | Normal NAD+/NADH ratio | - | 9 | 0.1–20 |
vu,n | Normal filtered demand | - | 1 | 0.7–1.3 |
σe,0 | Parameter in elastic tension relationship | mmHg | 0.143 | 0.114–0.171 |
RCO2 | Autoregulatory reactivity to carbon dioxide | - | 2.2 | 1.5–2.9 |
ε0NADH | Standard redox potential for NADH | mV | −320 | −384−-256 |
Δpn | Normal value of Δp (proton-motive force) | mV−1 | 168.611 | 118.028–219.194 |
COXtis | Concentration of COX in tissue | mM | 0.006 | 0.004–0.007 |
Llk0 | Constant controlling depending of leak rate Llk on Δp | mM s−1 | 0.004 | 0.003–0.006 |
p2 | Proton cost of reaction reducing a3 | − | 4 | 2.8–5.2 |