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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: J Med Primatol. 2019 Apr 2;48(3):192–196. doi: 10.1111/jmp.12410

Figure 1.

Figure 1.

A-I. Cutaneous epitheliotropic lymphoma in a baboon.

A) Skin. Neoplasm composed of sheets of round cells consistent with intermediate-sized lymphocytes with distinct cell borders, oval to indented nuclei with dense to coarsely stippled chromatin. H&E.

B) Rare areas of lymphocytes infiltrating the epidermis. H&E.

C) Scattered eosinophils are present admixed with the neoplastic cells. H&E.

D) Immunohistochemistry for CD3. Over 90% of the neoplastic cells are CD3+. DAB.

E) Immunohistochemistry for CD3. Note the tropism to epidermis and adnexal structures (hair follicle epithelium). DAB.

F) Immunohistochemistry for CD3. Note hair follicles surrounded and infiltrated by neoplastic cells. DAB.

G) Immunohistochemistry for CD4. Over 90% of the neoplastic cells are CD4+. DAB.

H) Immunohistochemistry for CD20. Note clusters of few (less than 5%) CD20+ lymphocytes. DAB. Inset: Higher magnification of CD20+ cells.

I) Immunohistochemistry for CD68. Note few (less than 5%) CD68+ macrophages. DAB. Inset: Higher magnification of CD68+ cells.