Table 3. Pathways of target genes from the 40 miRNAs differentially expressed between tumor and healthy tissue of colorectal cancer patients.

KEGG pathway	P value1	Genes2	miRNAs3
Prion diseases	<0.0001	1	2
Morphine addiction	<0.0001	44	10
Mucin type O-Glycan biosynthesis	<0.0001	13	7
ECM-receptor interaction	<0.0001	26	8
Fatty acid biosynthesis	<0.0001	5	1
Signaling pathways regulating pluripotency of stem cells	<0.0001	70	8
TGF-beta signaling pathway	<0.0001	38	8
GABAergic synapse	0.0001	28	8
Axon guidance	0.0001	68	6
Thyroid hormone signaling pathway	0.0006	34	7
Proteoglycans in cancer	0.0007	64	5
Glioma	0.0050	28	7
FoxO signaling pathway	0.0131	56	5
Prolactin signaling pathway	0.01325	42	7
Estrogen signaling pathway	0.02071	24	4
Renal cell carcinoma	0.0211	28	5

¹Only pathways with P values lower than 0.05 were considered as significant

²Number of genes affected in the pathway by the regulated miRNAs

³Number of miRNAs differentially expressed that have a target gene in the pathway