Table 11. Warning signs as predictors for level of care and severe outcome (univariate regression analysis).

Warning sign (predictor)	Dependent variable
	Level III of care				Severe outcome
	OR	95% CI		p-value	OR	95% CI		p-value
Persistent vomiting	2·05	0·91	4·6	0·085	0·53	0·12	2·31	0·396
Abdominal pain	0·70	0·35	1·38	0·301	0·76	0·33	1·72	0·507
Abdominal tenderness	0·86	0·34	2·17	0·752	2·22	0·92	5·40	0·077
Clinical fluid accumulation	1·27	0·36	4·50	0·710	2·25	0·62	8·18	0·220
Mucosal bleeding	1·73	0·82	3·67	0·152	0·80	0·27	2·41	0·798
Hepatomegaly >2 cm	0·33	0·04	2·53	0·288	3·70	1·26	10·85	0·017*
Laboratory warning signs#	4·97	2·35	10·50	<0·001*	6·89	2·90	16·37	<0·001*

*statistically significant result (p<0·05).

^#Laboratory warning signs: hemoconcentration with concurrent drop in the platelets count.

Abbreviations, OR: odds-ratio; CI: confidence interval.

Multivariate regression model including hepatomegaly and lab warning signs as predictors of severe outcome showed OR [95% CI] = 2·53 [0·80–8·04], p = 0·115 and 6·14 [2·53–14·88], p<0·001, respectively.