Table 2. Multivariable analysis for the 107 cohorts.

Variable	Cox Multivariable Analysis for OS			Cox Multivariable Analysis for DFS			Cox Multivariable Analysis for DMFS			Cox Multivariable Analysis for LRFS
	HR	95% Cl	P	HR	95% Cl	P	HR	95% Cl	P	HR	95% Cl	P
Gender
Female	reference			reference			reference			reference
Male	1.102	0.534–2.273	0.793	1.280	0.622–2.632	0.503	1.804	0.669–4.864	0.244	0.807	0.278–2.347	0.694
Age (years)
≤50	reference			reference			reference			reference
>50	1.405	0.821–2.402	0.215	1.284	0.760–2.169	0.351	1.849	0.939–3.641	0.076	0.820	0.359–1.873	0.638
T stage
T1–T2	reference			reference			reference			reference
T3–T4	1.081	0.440–2.655	0.865	0.968	0.403–2.328	0.943	0.891	0.302–2.628	0.835	1.142	0.264–4.946	0.859
N stage
N0–N1	reference			reference			reference			reference
N2–N3	1.172	0.464–2.948	0.737	1.027	0.415–2.545	0.954	1.249	0.404–3.860	0.699	0.883	0.207–3.766	0.866
Clinical stage
I–II	reference			reference			reference			reference
III–IV	1.219	0.438–3.395	0.704	1.201	0.443–3.258	0.718	1.322	0.382–4.574	0.659	1.009	0.196–5.181	0.992
chemotherapy
No	reference			reference			reference			reference
Yes	0.536	0.277–1.037	0.064	0.570	0.307–1.058	0.075	0.586	0.262–1.308	0.192	0.686	0.270–1.741	0.427
NKILA expression
Low	reference			reference			reference			reference
High	0.327	0.171–0.623	0.001	0.290	0.153–0.549	0.001	0.353	0.159–0.781	0.010	0.227	0.077–0.670	0.007

Abbreviations: HR, hazard ratio; 95%CI, 95% confidence interval; OS, overall survival; DFS, disease-free survival; DMFS, distant metastasis-free survival; LRFS, local recurrence-free survival