Table 4. Validation of the ranges of the top 6 parameters obtained with reassignment for both a negative and a positive control of HXK over XTR.

	Unconstrained parameters	Negative control (${\mathit{C}}_{\mathit{H}\mathit{X}\mathit{K}}^{\mathit{X}\mathit{T}\mathit{R}}<\mathbf{0}$)	Positive control (${\mathit{C}}_{\mathit{H}\mathit{X}\mathit{K}}^{\mathit{X}\mathit{T}\mathit{R}}>\mathbf{0}$)
$\mathbf{m}\mathbf{e}\mathbf{a}\mathbf{n}\left({\mathit{C}}_{\mathit{H}\mathit{X}\mathit{K}}^{\mathit{X}\mathit{T}\mathit{R}}\right)$	0.005	-0.13	0.21
% of negative ${\mathit{C}}_{\mathit{H}\mathit{X}\mathit{K}}^{\mathit{X}\mathit{T}\mathit{R}}$	47	79.4	11.4
% of positive ${\mathit{C}}_{\mathit{H}\mathit{X}\mathit{K}}^{\mathit{X}\mathit{T}\mathit{R}}$	53	20.6	88.6