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. Author manuscript; available in PMC: 2019 Aug 30.
Published in final edited form as: Int J Pharm. 2018 Apr 23;545(1-2):295–305. doi: 10.1016/j.ijpharm.2018.04.051

Scheme 1.

Scheme 1

Synthesis scheme and molecular structure of PCDP. i) Traut’s reagent in 0.1 M sodium phosphate buffer, RT, 4 h, ii) SPDP in DMF:0.1 M sodium phosphate buffer co-solvent (1:9), RT, 4 h, iii) 50 mM phosphate buffer, RT, 12 h.