Table 1.
Time (hours post induction) | Control | Firocoxib | Grapriprant |
---|---|---|---|
Experiment 1 - treatments administered 2 h prior to induction of arthritis | |||
1.5 | 0.49 (0.00–0.89)a | 0.90 (0.73–0.99) | 0.76 (0.00–1.05)b |
3 | 0.00 (0.00–0.00)c | 0.86 (0.75–0.98)c | 0.26 (0.00–0.83)d |
5 | 0.00 (0.00–0.00)c | 0.80 (0.00–1.04)c | 0.00 (0.00–0.00)d |
7 | 0.00 (0.00–0.00)c | 0.95 (0.69–1.05)c | 0.00 (0.00–0.00)d |
10 | 0.00 (0.00–0.00)c | 1.06 (0.98–1.17)c | 0.16 (0.00–0.98)d |
Experiment 2 - treatments administered 14 h prior to induction of arthritis | |||
1.5 | 0.28 (0.00–0.66)a | 0.75 (0.00–0.97) | 0.61 (0.00–1.02)b |
3 | 0.00 (0.00–0.00) | 0.36 (0.00–0.84) | 0.00 (0.00–0.65) |
5 | 0.00d (0.00–0.00)d | 0.45 (0.00–0.99)d | 0.00 (0.00–0.00)e |
7 | 0.00 (0.00–0.00)c | 0.80 (0.00–1.07)c | 0.00 (0.00–0.00)d |
10 | 0.35 (0.00–0.87)f | 0.91 (0.66–1.05)f | 0.00 (0.00–0.00)g |
Different superscripts in the same row indicate statistically significant differences: a,b p = 0.026; c,d p < 0.001; e,d p = 0.033; f,g p ≤ 0.006