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. 2019 Aug 29;7:233. doi: 10.1186/s40425-019-0703-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — PD-L2 in PDAC. a Stratification of PD-L2 expression in PDAC cells (scales bar: 20 μm) and in the stroma. b Statistical results of correlation between intratumoral and stromal PD-L2 using the χ² test. c Expression of CD3, CD8 and FOXP3 in PDAC TILs. d Comparison between intratumoral and stromal densities of CD3+, CD8+ and FOXP3+ T cells in PDAC using paired t tests. e Scatter plots with linear regression for 4 immune markers using Pearson’s correlation. f Relation among densities of CD3+, CD8+, and FOXP3+ T cells based on PD-L2 expression levels using the Mann-Whitney U test. * P < 0.05; **P < 0.01; ***P < 0.001