(A) Body mass, (B) caloric consumption, (C) water intake, (D) locomotor activity, and (E) regional adipose tissue mass, as well as indirect calorimetry measurements of (F) oxygen consumption (VO2), (G) carbon dioxide production (VCO2), (H) respiratory exchange ratio (RER), and (I) energy expenditure following administration (i.p.) of 6-OHDA (6) to ablate peripheral sympathetic nerves, or vehicle control (Veh), in high fat diet and normal chow fed mice. n=7–8 for all. Two-way ANOVA with Tukey’s post-hoc test for all. *p<0.05 vs. normal chow, #p<0.05 vs. high fat diet vehicle.