. Author manuscript; available in PMC: 2019 Aug 30.

Published in final edited form as: Xenotransplantation. 2019 Apr 29;26(4):e12517. doi: 10.1111/xen.12517

Table 3:

Transgenic expression of one or more human complement-regulatory proteins protects pig-to-nonhuman primate heart grafts

Genetic background (or model)	Survival without immunosuppressive therapy (Ref)	Survival with immunosuppressive therapy (Ref)
Wild-type	Mean 20–80 minutes¹³⁹	15–75 minutes (n=4), 5 days (n=1)¹³⁹
Anti-Gal antibody depletion	Mean 15 days¹⁴¹	<15 days¹⁴²
GTKO		Mean 78 days (59–179d)¹⁴²
hCD46 expression	Mean 5.25 days (60min-16d)¹³⁹	Mean 96 days (15–137d, n=7)¹⁴³
hCD55	Mean 5.1 days¹⁴⁴	Mean 27 days (4–139d)¹⁴⁵
hCD59		Mean 2.5–3.0 hours¹⁴⁶
CD55+CD59		85–130 hours¹⁴⁷
GTKO+hCD46		Up to 236 days¹⁴⁸
GTKO+ hCD55		Mean 28 days¹³⁴
GTKO+ hCD55+CD46		Mean 21 days (15–33d)¹⁴⁹
GTKO+hCD46+hTBM		<945days¹⁵⁰

Abbreviations: TBM=thrombomodulin.