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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: J Physiol. 2019 Jul 27;597(17):4503–4519. doi: 10.1113/JP278338

Table 2.

Isolated red blood cell gases

pH PO2 (mmHg) PCO2 (mmHg) tHb (g/dL) FO2Hb (%) FHHb (%)
Study 1 Normoxia Young Saline 7.327±0.010 112.1±1.9 35.4±1.0 7.1±0.2 95.1±0.2 3.4±0.1
Y-27632 7.327±0.009 112.5±2.5 34.4±0.7 7.1±0.2 95.1±0.2 3.3±0.1
Older Saline 7.344±0.009 111.8±2.7 35.0±0.7 7.7±0.3 95.0±0.2 3.6±0.2
Y-27632 7.360±0.006*† 114.0±2.7* 34.1±0.4 7.4±0.2 95.2±0.2 3.4±0.1*
Hypoxia Young Saline 7.340±0.010 19.3±1.2 36.5±1.1 7.1±0.2 24.1±2.8 72.1±2.6
Y-27632 7.340±0.010 19.6±1.4 36.6±0.8 7.1±0.2 24.1±2.8 72.2±2.7
Older Saline 7.367±0.010 18.7±1.7 35.8±1.0 7.6±0.3 23.1±3.4 73.1±3.2
Y-27632 7.375±0.008† 18.2±1.4 35.2±0.4 7.3±0.2 21.5±3.0 74.4±2.9
Normoxia Young Saline 7.324±0.007 109.6±1.1 34.8±0.6 6.7±0.1 94.6±0.2 3.6±0.1
Diamide 7.319±0.007 110.0±0.8 35.1±0.6 6.7±0.1 94.6±0.2 3.5±0.1
Older Saline 7.314±0.008 111.8±1.0 33.9±0.9 6.5±0.2 94.5±0.1 3.7±0.2
Diamide 7.306±0.009 111.9±1.2 34.5±0.6 6.5±0.2 94.5±0.3 3.5±0.2
Hypoxia Young Saline 7.348±0.007 16.8±0.8 34.6±0.6 6.5±0.1 17.4±1.2 78.1±1.2
Diamide 7.347±0.007 17.5±1.0 35.8±0.7 6.6±0.2 19.6±2.1 76.1±1.9
Older Saline 7.332±0.010 18.1±1.1 35.0±0.5 6.4±0.2 17.9±2.0 77.7±1.9
Diamide 7.339±0.016 21.1±1.7† 34.5±1.2 6.6±0.2 28.8±3.9 67.3±3.6
Study 2 Normoxia Young DMF 7.330±0.010 113.1±1.2 34.9±0.6 6.6±0.1 94.9±0.2 3.8±0.1
Cilostazol 7.325±0.012 114.1±1.7 34.7±0.7 6.5±0.2 94.9±0.2 3.7±0.1
Older DMF 7.362±0.013 115.7±1.3 35.4±0.8 6.8±0.1 95.1±0.1 3.3±0.2
Cilostazol 7.350±0.013* 114.0±1.1 37.0±0.6 6.8±0.2 95.2±0.1 3.5±0.1*
Hypoxia Young DMF 7.352±0.010 23.5±1.1 34.8±0.5 6.9±0.2 33.3±3.2 63.2±3.0
Cilostazol 7.339±0.009 24.5±1.2 36.4±0.8* 6.8±0.2 35.7±3.2 60.8±2.9
Older DMF 7.375±0.012 24.3±0.6 36.2±0.5 7.0±0.1 34.8±1.7 61.9±1.6
Cilostazol 7.361±0.013 24.1±0.6 36.0±0.7 7.0±0.2 35.5±1.8 61.1±1.7

PO2: partial pressure of oxygen, PCO2: partial pressure of carbon dioxide, tHb: total haemoglobin, FO2Hb: fraction of oxygenated haemoglobin, FHHb: fraction of deoxygenated haemoglobin.

*

P < 0.05 vs. vehicle control (within age)

†

P < 0.05 vs. young (within condition)