Table 4.
Sensitivity, specificity, PPV, PNV for each cut-point of proposed score (1 point for each category variable) using Hospital Maciel, Montevideo, and PLATINO study samples
| Score | Sensitivity | Specificity | PPV | PNV | NNT |
|---|---|---|---|---|---|
| % (95% CI) | % (95% CI) | % (95% CI) | % (95% CI) | ||
| Post-bronchodilator FEV1/FVC <0.70 definition as outcome | |||||
| Hospital Maciel, Montevideo | |||||
| ≥1 | – | – | – | – | – |
| ≥2 | 99.3 (98.0; 99.9) | 0.9 (0.3; 2.2) | 45.1 (42.0; 48.3) | 62.5 (24.5; 91.5) | 13 |
| ≥3 | 97.5 (95.6; 98.7) | 6.9 (4.9; 9.4) | 46.2 (43.0; 49.5) | 77.1 (62.7; 88.0) | 4 |
| ≥4 | 95.2 (92.8; 97.0) | 18.9 (15.6; 22.5) | 49.1 (45.7; 52.5) | 82.8 (74.9; 89.0) | 3 |
| ≥5 | 85.4 (81.8; 88.6) | 37.6 (33.5; 41.8) | 52.9 (49.1; 56.6) | 75.8 (70.2; 80.9) | 3 |
| ≥6 | 69.0 (64.5; 73.3) | 62.1 (57.8; 66.2) | 59.9 (55.5; 64.2) | 70.9 (66.6; 75.0) | 3 |
| ≥7 | 44.6 (39.9; 49.4) | 82.6 (79.1; 85.7) | 67.8 (62.1; 73.2) | 64.5 (60.8; 68.1) | 3 |
| ≥8 | 21.2 (17.5; 25.3) | 94.0 (91.7; 95.9) | 74.4 (65.8; 81.8) | 59.2 (55.9; 62.6) | 3 |
| ≥9 | 2.3 (1.1; 4.2) | 100.0 (99.3; 100.0) | 100.0 (69.2; 100.0) | 55.5 (52.3; 58.7) | 2 |
| PLATINO study | |||||
| ≥1 | 98.4 (96.8; 99.4) | 7.3 (6.2; 8.6) | 19.6 (18.0; 21.3) | 95.3 (90.6; 98.1) | 7 |
| ≥2 | 93.0 (90.3; 95.2) | 25.2 (23.2; 27.2) | 22.2 (20.4; 24.2) | 94.0 (91.6; 95.9) | 6 |
| ≥3 | 85.4 (81.8; 88.5) | 46.9 (44.7; 49.2) | 27.0 (24.7; 29.4) | 93.3 (91.6; 94.8) | 5 |
| ≥4 | 66.7 (63.1; 72.0) | 66.5 (64.4; 68.6) | 31.7 (28.8; 34.8) | 89.9 (88.3; 91.5) | 5 |
| ≥5 | 51.5 (46.7; 56.2) | 81.6 (79.8; 83.3) | 39.1 (35.1; 43.2) | 88.0 (86.4; 89.4) | 4 |
| ≥6 | 31.5 (27.2; 36.0) | 91.3 (89.9; 92.5) | 45.3 (39.7; 51.0) | 85.3 (83.7; 86.8) | 3 |
| ≥7 | 13.5 (10.4; 17.0) | 97.6 (96.8; 98.2) | 56.1 (46.1; 65.7) | 83.1 (81.5; 84.6) | 3 |
| ≥8 | 6.3 (4.2; 9.0) | 99.6 (99.2; 99.8) | 77.8 (60.8; 89.9) | 82.2 (80.6; 83.7) | 2 |
| ≥9 | 1.4 (0.5; 2.9) | 99.9 (99.7; 100.0) | 85.7 (42.1; 99.6) | 81.5 (79.9; 83.1) | 1 |
| Post-bronchodilator LLN FEV1/FVC definition as outcome | |||||
| Hospital Maciel-Montevideo | |||||
| ≥1 | – | – | – | – | – |
| ≥2 | 98.9 (97.3; 99.7) | 0.7 (0.2; 1.7) | 38.3 (35.2; 41.5) | 50.0 (15.7; 84.3) | – |
| ≥3 | 96.8 (94.5; 98.3) | 6.0 (4.2; 8.2) | 39.1 (35.9; 42.3) | 75.0 (60.4; 86.4) | 7 |
| ≥4 | 94.4 (91.5; 96.5) | 16.8 (13.9; 20.1) | 41.4 (38.1; 44.8) | 82.8 (74.9; 89.0) | 4 |
| ≥5 | 83.2 (79.0; 86.8) | 33.7 (29.9; 37.6) | 43.9 (40.2; 47.6) | 76.2 (70.6; 81.2) | 5 |
| ≥6 | 68.4 (63.5; 73.1) | 58.3 (54.3; 62.3) | 50.6 (46.1; 55.0) | 74.8 (70.6; 78.7) | 4 |
| ≥7 | 43.9 (38.8; 49.0) | 79.1 (75.7; 82.3) | 56.7 (50.8; 62.5) | 69.3 (65.7; 72.8) | 4 |
| ≥8 | 21.1 (17.1; 25.6) | 92.3 (89.9; 94.3) | 63.2 (54.1; 71.6) | 65.3 (61.9; 68.5) | 4 |
| ≥9 | 2.1 (0.9; 4.2) | 99.7 (98.8; 100.0) | 80.0 (44.4; 97.5) | 62.0 (58.9; 65.1) | 2 |
| PLATINO study | |||||
| ≥1 | 97.8 (95.7; 99.0) | 7.1 (6.0; 8.3) | 16.1 (14.6; 17.8) | 94.6 (89.6; 97.6) | 9 |
| ≥2 | 90.3 (86.8; 93.2) | 24.3 (22.4; 26.2) | 17.9 (16.2; 19.7) | 93.2 (90.7; 95.2) | 9 |
| ≥3 | 82.0 (77.6; 85.8) | 45.3 (43.1; 47.5) | 21.5 (19.4; 23.8) | 93.2 (91.4; 94.7) | 7 |
| ≥4 | 64.3 (59.1; 69.2) | 64.7 (62.6; 66.9) | 25.0 (22.2; 27.9) | 90.8 (89.2; 92.3) | 6 |
| ≥5 | 49.0 (43.8; 54.3) | 80.1 (78.3; 81.9) | 31.1 (27.3; 35.1) | 89.6 (88.1; 91.0) | 5 |
| ≥6 | 30.7 (26.0; 35.8) | 90.3 (88.9; 91.6) | 36.8 (61.3; 42.5) | 87.7 (86.2; 89.1) | 4 |
| ≥7 | 14.1 (10.7; 18.2) | 97.3 (96.5; 98.0) | 49.0 (39.1; 59.0) | 86.1 (84.6; 87.5) | 3 |
| ≥8 | 7.2 (4.8; 10.4) | 99.6 (99.2; 99.8) | 76.5 (58.8; 89.3) | 85.4 (83.9; 86.9) | 2 |
| ≥9 | 1.7 (0.6; 3.6) | 99.9 (99.7; 100.0) | 85.7 (42.1; 99.6) | 84.8 (83.2; 86.2) | 1 |
Abbreviations: PPV, predictive positive value; PNV, predictive negative value.