. 2019 Aug 22;12(11):1496–1503. doi: 10.1016/j.tranon.2019.05.020

Table 3.

Role of radiation related to cancer-specific death in stratified Cox regression analysis

Patient category∗	Level	Cancer-specific death^⁎⁎		HR (95% CI)^⁎⁎⁎	P-value	Interaction term
Patient category∗	Level	Radiation	No radiation	HR (95% CI)^⁎⁎⁎	P-value	P-value ^#
Cancer-directed surgery	No cancer-directed surgery	312/424	2194/2614	0.61 [0.54, 0.69]	<.0001	.002
	Tumor resection	82/166	361/816	1.00 [0.79, 1.27]	.73
	Ablation	3/5	28/53	0.66 [0.20, 2.19]	.46
Age	<70 y	282/429	1555/2189	0.72 [0.63,0.81]	<.0001	.37
Age	≥70 y	118/170	1060/1337	0.66 [0.54, 0.79]	<.0001	.37
Sex	Female	204/316	1282/1770	0.66 [0.57, 0.77]	<.0001	.55
Sex	Male	196/283	1333/1756	0.71 [0.61,0.82]	<.0001	.55
T stage	T0	0/2	11/11	-	-	.99
	T1	111/196	747/1139	0.71 [0.58, 0.87]	.0008
	T2	93/157	580/845	0.71 [0.57, 0.88]	.002
	T3	100/122	551/668	0.72 [0.58, 0.89]	.003
	T4	59/76	289/370	0.65 [0.49, 0.87]	.003
N stage	N0	240/389	1645/2332	0.68 [0.60, 0.78]	<.0001	.91
N stage	N1	128/175	666/845	0.65 [0.53, 0.78]	<.0001	.91
M stage	M0	256/424	1367/2057	0.73 [0.64, 0.84]	<.0001	.73
M stage	M1	144/175	1248/1469	0.76 [0.64, 0.90]	.002	.73

Note:

Patient category∗: patients were categorized by diagnosis time (2004–2009, 2010–2013) and N0 / N1 stages. N0 category included patients with no lymph node metastasis, while N1 category included patients with lymph node metastasis.

Cancer-specific death^⁎⁎ was demonstrated as ICC-specific death number (numerator) divided by number of patients treated by radiation/no radiation in each patients category∗ with or without primary tumor surgery.

HR (95% CI)∗∗∗ showed the hazard ratio (95% confidence interval) of cancer-specific death among radiation patients vs no radiation patients in subgroups.

P-value ^# for interaction term indicated the different effect of radiation among stratified subgroups.