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Gene expression analysis of hepatic Phase I and II enzymes involved in APAP metabolism. A) Cytochrome p450s: 1a2, 2e1 and 3a11 (Phase I); B) Ugt1a1, 1a6 and Sul1a1 (Phase II). Data are presented as mean ± S.E.M. (p ≤ 0.05). An asterisk “*” denotes significant difference between WT and Mrp4−/− mice.
