The activities of liver enzymes, a; glutathione peroxidase, b; glutathione reductase, c; glutathione-s-transferase, d; reduced glutathione and e; lipid peroxide in control group (G1), zinc oxide nanoparticles groups (G2and G3) and zinc oxide nanoparticles with vitamin mixture groups (G4 and G5). Values are Expressed as mean ± SD (n 20). Significance levels (p < 0.05) observed are: a = in comparison to control group, b = when 2 mg ZONPs groups versus 1 mg ZONPs groups are compared, c = when ZONPs + vitamins groups versus their respective ZONPs groups are compared, * = when 15 days treated groups compared with their respective 7 days treated groups.