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. 2019 Aug 26;5(8):e02378. doi: 10.1016/j.heliyon.2019.e02378

Fig. 2.

Fig. 2

Interaction network and biological process analysis of 25 hub genes. (A) Hub genes and their co-expression genes were analyzed using cBioPortal. Nodes with bold black outline represent hub genes. Nodes with thin black outline represent the co-expression genes. (B) Hierarchical clustering of 25 hub genes was performed using UCSC Xena. In the first column graph on the right, upregulation of genes is marked in red; downregulation of genes is marked in green. In the second column graph on the right, there are three phases of cycles, including G1 (brown), G2 (purple), and G3 (yellow).