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. 2019 Aug 30;9:12605. doi: 10.1038/s41598-019-49027-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Characterization of aggresomes in pediatric medulloblastoma tumor samples. (A) IHC analysis of vimentin identified three different patterns. Negative; vimentin immunoreactivity was absent or only observed in infiltrating blood vessels. Localized; observed in desmoplastic/nodular variant, where juxta-nuclear dot-like vimentin was identified in the interstitial space between nodules. Uniform distribution; of juxta-nuclear dot-like were identified in classic and LC/A histological subtypes. Red arrows show para nuclear localization of vimentin indicative of aggresomes formation. (B) IF analysis of CCHE-188 cells. Cells were immunostained with mouse anti-vimentin and rabbit anti-HDAC6 then visualized using Alexa Fluor 488 goat anti-mouse and Alexa Fluor 555 goat anti-rabbit respectively. Cells were counter-stained using DAPI. (C) Bar Plot of the distribution of aggresomes percentages among different molecular subgroups, subdivided according to histological variant. p-values were calculated using Kruskal-Wallis test.