Subject | Chemistry (General) |
Specific subject area | Bioorganic and Medical Chemistry |
Type of data | Images Graphs Figures |
How data were acquired | NMR spectroscopy (JNM-ECX400P, JEOL), microscopy (Olympus's CLX41), western blot imaging system (LAS500, AB Biosciences), microplate reader (VersaMax, Molecular Devices). |
Data format | Analyzed. |
Parameters for data collection | Synthesis and cell plasticity/anti-cancer activity after treatment with a novel indirubin derivative, LDD-1819. |
Description of data collection | The parameters were as follows: 1) 1H NMR spectra of the chemical structure of compound LDD-1819. 2) Cell viability after LDD-1819 treatment. 3) Microscopic observation of myotube cellularization. 4) Quantitative PCR analysis of gene expression related to myogenesis, apoptosis or cancer cell invasion. 5) Inhibition activity against glycogen synthase kinase-3 β and aurora kinase A. |
Data source location | Gwangju Republic of Korea (South Korea). |
Data accessibility | With the article |
Related research article | Author's name: Kim WH, Jeong P, Kim SW, Cho H, Lee JM, Seo S, Shen H, Ahn Y, Jung DW, Kim YC, Williams DR. Title: A novel indirubin derivative that increases somatic cell plasticity and inhibits tumorigenicity Journal: Bioorganic & Medicinal Chemistry. https://doi.org/10.1016/j.bmc.2019.05.025 |