Fig. 6.

Tan IIA activated the SIRT1-PGC1α pathways to sustain the mitochondrial homeostasis and alleviate the damage to cardiac microvasculature under IR injury. a, b Western blot was used to detect the alterations about SIRT1 and PGC1α. c The caspase-9 activity was measured to reflect the mitochondrial apoptosis with SIRT1 activation or inhibition. d, e Mitochondrial potential was observed via JC-1 staining with SIRT1 activation or inhibition. *P < 0.05 vs. Ctrl group; ^#P < 0.05 vs. IR group; ^@P < 0.05 vs. Tan IIA group. Experiments were repeated three times, and the data represent the mean ± SEM