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. 2019 Aug 12;116(35):17541–17546. doi: 10.1073/pnas.1905902116

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Fig. 4. — The nNOS^S1412A mutation enhances classical NO-cGMP signaling. (A) Lack of eNOS (eNOS KO) does not alter low-frequency EFS relaxation of nNOS^S1412A. (B) nNOS^S1412A and nNOSα KO ilea are more sensitive than WT to SNP-induced relaxation. IC₅₀ (μM SNP) and 95% confidence intervals are in symbol legend. (C) PDE5 is decreased in nNOS^S1412A compared with WT ilea. Total nNOS, sGCβ, and PKG1 expression are unchanged. (D) Quantification of C. Different letters: P < 0.05 via Tukey test. ¶: Data repeated from Fig. 3 for comparison. Double Hom: eNOS KO nNOS^S1412A double mutant homozygote. *: IC₅₀ significantly different from WT. n.s.: not significant. N: ileal rings.