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. 2019 Jul 24;116(35):17419–17428. doi: 10.1073/pnas.1904480116

Fig. 1.

Fig. 1.

Intrinsic expression of viperin in adipose tissues regulates fat metabolism and heat production. (A) Expression of viperin in various tissues of SPF and GF mice. (B) Gross morphology of the adipose tissues eWAT, iWAT, and BAT of WT and viperin KO mice. (C–I) WT and viperin KO mice were fed RC or an HFD from age 15 wk to 30 wk (15 wk on diet). Body weight (n = 4–7) (C); body composition (n = 4–7) (D); expression of viperin in adipose tissues (n = 3) (E); representative H&E-stained sections from adipose tissues and liver (Scale bar: 200 μm) (F); serum metabolites (HDLC, TG, TCHO, and GLU), AST, and ALT (n = 4–7) (G); i.p. glucose tolerance test, including area under the curve (n = 7–8) (H); and heat production rates (n = 4–7; indirect calorimetry) (I) of WT and viperin KO mice fed RC or an HFD. Data are presented as mean ± SEM of biologically independent samples. *P < 0.05; **P < 0.01; ***P < 0.001 vs. WT on the same diet.