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. 2019 Jul 24;116(35):17419–17428. doi: 10.1073/pnas.1904480116

Fig. 5.

Fig. 5.

Viperin regulates fatty acid β-oxidation–mediated thermogenesis in an adipocyte-autonomous manner. SVF is isolated from the BAT and differentiated into mature brown adipocytes. (A) Relative mRNA levels of adipogenesis-, thermogenesis-, and fatty acid β-oxidation–related genes in brown adipocytes during differentiation. (B and C) Relative mRNA levels of thermogenesis-related genes in CL-treated brown adipocytes (B) and etomoxir (ETO; Left)- or ranolazine (RAN; Right)-treated brown adipocytes (C). (D) OCR and mitochondrial parameters (basal respiration, ATP production, proton leak, and maximal respiration) in WT and viperin KO brown adipocytes after CL treatment (Top) or ETO treatment (Bottom). Data are presented as mean ± SEM of 2 independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001 vs. WT for the same treatment.