Table 1.

Lysosomal enzyme activity in the plasma of Gnptab Ser321Gly mice

Animal group	β-Galactosidase	β-Glucuronidase	β-Hexosaminidase	β-Mannosidase	α-Mannosidase
Male
Wild-type (n = 9)	24.95 ± 5	9.20 ± 1.8	206.73 ± 20	52.26 ± 3.7	117.33 ± 20.9
Ser321Gly (n = 8)	23.00 ± 6	7.72 ± 1.4	260.88 ± 35	112.39 ± 22.9	279.34 ± 77.1
P value	0.46	0.09	0.001	<0.0001	<0.0001
Female
Wild-type (n = 7)	24.49 ± 3.9	8.70 ± 1.1	237.32 ± 17.3	36.12 ± 1.7	83.51 ± 10.8
Ser321Gly (n = 7)	28.00 ± 5.5	10.20 ± 2.0	390.81 ± 105.8	90.78 ± 11.1	272.3 ± 22.7
P value	0.19	0.12	0.0025	<0.0001	<0.0001
Merged
Wild-type	24.75 ± 4.5	8.98 ± 1.6	220.11 ± 24.2	45.20 ± 8.8	102.53 ± 24.1
Ser321Gly	25.34 ± 5.9	8.87 ± 2.1	321.51 ± 99.5	102.30 ± 21.0	276.05 ± 56.6
P value	0.38	0.44	<0.001	<0.0001	<0.0001

Activity is expressed as nanomole 4-methyumbelliferone cleaved per hour per milliliter of plasma.