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. 2019 Aug 8;116(35):17438–17443. doi: 10.1073/pnas.1903150116

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Copyright © 2019 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 3. — MiR223 KO mice exhibit increased unprovoked chromosomal aberrations. (A) Representative images for PARP1 protein assessed by immunohistology in the bone marrow of miR223 wild-type (WT) and genetically deleted mice. (B) Percentage of PARP1-expressing cells in the bone marrow of miR223^−/− and WT mice. (C) Representative confocal images showing metaphase chromosomes in the MiR223^−/− and WT mouse bone marrow. Cruciform structures indicative of chromosomal fusions are shown with arrows. (D) Percentage of chromosomal aberrations per metaphase in MiR223^−/− and WT mice.