Table 2.
miRNAs regulated by ATRA in AML cell lines
| Study (reference and country) | Cell type | ATRA treatment | miRNAs upregulated | miRNAs downregulated |
|---|---|---|---|---|
|
Garzon et al. (2007) [23] United States |
NB4 | 10−1 μmol /L for 4 days | 9; miR-15a, miR-15b, miR-16-1, let-7a-3, let-7c, let-7d, miR-223, miR-342, and miR-107; most significant: miR-15b | miR-181b |
|
Marchis et al. (2009) [40] Italy |
NB4 | 1 μmol/L for 72 h | miR-342 | – |
| Gao et al. (2011) [41] China | U937, HL60, NB4 and leukemic fresh cell lines | 1 μmol/L for 72 h | 2; miR-15a and miR-16-1; most significant: miR-15a | – |
| Lin et al. (2011) [42] China | NB4, HL60 and K562 | 1 μmol/L for 72 h | – | miR-125b |
| Morris et al. (2013) [43] United States | HL60, NB4, PL21, and THP-1 | 10−3 μmol/L to 1 μmol/L for 21 days | – | miR-150 |
| Zhuang et al. (2014) [44] China | NB4 | 1 μmol/L for 36 h | – | miR-181a |
|
Lin et al. (2015) [45] China |
HL60 and NB4 | 3 μmol/L ATRA for 72 h (HL60) and 2 μmol/L ATRA for 4 days (NB4) | miR-638 | – |
| Bräuer-Hartmann et al. (2015) [46] Germany | NB4 | 10−1 μmol/L for 24 h | – | miR-181 cluster (miR-181a, miR-181b, miR-181c and miR-181d); most significant: miR-181a and miR-181b |
| Yan et al. (2016) [47] United States | HL60 | 10− 1 and 1 μmol/L for 72 h | – | miR-17–92 cluster (miR-17, miR-18a, miR-19b, miR-20a and miR-92); most significant: miR-20a |