. 2019 Aug 30;19:866. doi: 10.1186/s12885-019-6081-7

Table 3.

miRNAs regulated by ATRA in breast carcinoma cell lines

Study (reference and country)	Cell type	ATRA treatment	miRNAs upregulated	miRNAs downregulated
Terao et al. (2011) [48]	MCF-7	1 μmol/L for 72 h	miR-21	–
Khan et al. (2015) [49] Ireland	T47D and SK-BR-3	1 and 5 μmol/L for 24 h	miR-10a	–
Fisher et al. (2015) [50] Italy	SKBR3, MCF-7, MDA-MB-157	10⁻¹ μmol/L (SKBR3) and 1 μmol/L ATRA (MCF-7 and MDA-MB-157) for 36 h	13; mir-103¹; miR-1225-5p¹, miR-1268¹, miR-141, miR-188-5p¹, miR-19b¹, miR-200c¹, miR-21¹, miR-22¹, miR-513a-5p¹, miR-575¹, miR-642¹ and miR-664^1a	17; miR-15b¹², miR-96¹², miR-203¹², miR-183¹², miR-210-3p¹²³, miR-362-5p¹², miR-149¹², miR-125a-5p¹²³, miR-193a-5p¹², miR-185¹², miR-532-5p¹², miR-342-3p¹², miR-148a¹, miR-375¹, miR-193a-3p¹, miR-205¹ and miR-660^1a

Study (reference and country)

Cell type

ATRA treatment

miRNAs upregulated

miRNAs downregulated

Terao et al. (2011) [48]

MCF-7

1 μmol/L for 72 h

miR-21

–

Khan et al. (2015) [49]

Ireland

T47D and SK-BR-3

1 and 5 μmol/L for 24 h

miR-10a

–

Fisher et al. (2015) [50]

Italy

SKBR3, MCF-7, MDA-MB-157

10⁻¹ μmol/L (SKBR3) and 1 μmol/L ATRA (MCF-7 and MDA-MB-157) for 36 h

13; mir-103¹; miR-1225-5p¹, miR-1268¹, miR-141, miR-188-5p¹, miR-19b¹, miR-200c¹, miR-21¹, miR-22¹, miR-513a-5p¹, miR-575¹, miR-642¹ and miR-664^1a

17; miR-15b¹², miR-96¹², miR-203¹², miR-183¹², miR-210-3p¹²³, miR-362-5p¹², miR-149¹², miR-125a-5p¹²³, miR-193a-5p¹², miR-185¹², miR-532-5p¹², miR-342-3p¹², miR-148a¹, miR-375¹, miR-193a-3p¹, miR-205¹ and miR-660^1a

¹SKBR3 cell lines; ²MCF-7 cell lines; ³MDA-MB-157 cell lines; ^aAuthors did not mention the miRNAs most sensitive to ATRA treatment