. 2019 Aug 30;19:866. doi: 10.1186/s12885-019-6081-7

Table 4.

miRNAs regulated by ATRA in lung cancer cell lines

Study (reference and country)	Cell type	ATRA treatment	miRNAs upregulated	miRNAs downregulated
Zhu et al. (2015) [3] China	A549 and H1299	10 and 100 μmol/L for 24 h (A549); and 100 μmol/L for 72 h (H1299)	8; miR-594, miR-519b, miR-504, miR-512-3p, miR-363, miR-517a, miR-518a and miR95; most significant: 512-3p	5; mir-223, miR-196a, miR-369-3p, miR-146a and miR-142-3p^a
Chu et al. (2016) [4] China	H1299 and A549	10 and 100 μmol/L for 72 h	miR-512-5p	–

Study (reference and country)

Cell type

ATRA treatment

miRNAs upregulated

miRNAs downregulated

Zhu et al. (2015) [3]

China

A549 and H1299

10 and 100 μmol/L for 24 h (A549); and 100 μmol/L for 72 h (H1299)

8; miR-594, miR-519b, miR-504, miR-512-3p, miR-363, miR-517a, miR-518a and miR95; most significant: 512-3p

5; mir-223, miR-196a, miR-369-3p, miR-146a and miR-142-3p^a

Chu et al. (2016) [4]

China

H1299 and A549

10 and 100 μmol/L for 72 h

miR-512-5p

–

^aAuthors did not mention the miRNA most sensitive to ATRA treatment