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. 2019 Aug 31;12:81. doi: 10.1186/s13048-019-0557-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — DEGs and enrichment analysis between PIK3CA low group and PIK3CA high group. a Volcano plot of DEGs between PIK3CA low group and PIK3CA high group. Purple dots represent up-regulated genes in PIK3CA high group (log₂FC > 1, FDR < 0.01), whereas green dots represent up-regulated genes in PIK3CA low group (log₂FC > 1, FDR < 0.01). b GO and KEGG enrichment analysis of top 500 DEGs. c, d Heatmap of DEGs between PIK3CA low group and PIK3CA high group