Table 2.

Univariable and multivariable competing-risk regression model for single agent substitution and Cox proportional hazard model for Mortality

	Mortality				Single-drug substitution
	Univariable		Multivariable		Univariable		Multivariable
	Hazard ratio	p-value	Hazard ratio	p-value	Hazard ratio	p-value	Hazard ratio	p-value
Chronic hepatitis B
Negative	Ref.		Ref.		Ref.		Ref.
≤10,000 copies/mL	0.7 (0.2–2.3)	0.5	0.7 (0.2–2.3)	0.5	2.1 (1.2–3.9)	0.01	2.2 (1.2–4.1)	0.01
>10,000 copies/mL	2.6 (1.0–6.7)	0.05	3.1 (1.2–8.0)	0.02	2.6 (1.3–5.3)	0.01	2.3 (1.1–4.7)	0.02
WHO stage at ART initiation		<0.001		<0.001		0.03		0.002
I and II	Ref.		Ref.		Ref.		Ref.
III and IV	1.9 (1.1–3.7)		1.9 (1.1–3.6)		0.4 (0.1–0.9)		0.3 (0.1–0.8)
Age (years)		0.8		0.8		0.6		0.8
≤42	Ref.		Ref.		Ref.		Ref.
>42	0.9 (0.5–1.8)		0.9 (0.4–1.9)		0.9 (0.6–1.4)		1.1 (0.6–1.8)
Time-updated CD4, cells/mm3		0.06		0.003		0.003		0.002
<100	16.0 (3.1–45.6)		7.5 (1.4–39.2)		4.5 (1.9–10.2)		5.3 (2.3–12.3)
101–250	3.8 (0.7–20.8)		2.4 (0.4–13.0)		2.0 (0.9–4.1)		2.1 (1.1–4.5)
>250	Ref.		Ref.		Ref.		Ref.