Table I.

Main characteristics of the studies included in the meta-analysis.

Author	Year	Country	Ethnicity	Case (n)	Control	No. of control (n)	Sample	AUC	Sensitivity (%)	Specificity (%)
Amr	2016	Egypt	Caucasian	23	Patients with chronic hepatitis	17	Serum	0.943	100	81.2
Gedawy	2017	Egypt	Caucasian	30	Chronic liver diseases	20	Plasma	NA	93	90
Tomimaru	2012	Japan	Asian	126	30 chronic hepatitis (CH)	30	Plasma	0.773	61.1	83.3
Tomimaru	2012	Japan	Asian	126	50 healthy volunteers (HVs)	50	Plasma	0.953	87.3	92
Xu	2011	China	Asian	101	89 Healthy controls	89	Serum	0.87	84	73.5
Zhuang	2016	China	Asian	52	43 healthy controls	43	Serum	0.621	67.4	55.8
Liu	2012	China	Asian	57	59 hepatitis B carrier/healthy controls	59	Serum	0.865	89.47	71.19