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. 2019 Aug 28;7:e7568. doi: 10.7717/peerj.7568

Figure 2. Effect of NR repletion on the development of the NAFLD in aged mice.

Figure 2

The levels of AST (A), ALT (B), total cholesterol (C), triglyceride (D), and NAD (E) in serum of aged mice. (F) hepatic steatosis was reduced by NR administration in aged mice. The percentage of classified livers in each of the four steatosis categories in different groups was as follows: 0, no vacuolation; 1, 2 or 3 vacuoles; 2, less than 50% of fatty vacuolation; 3, more than 50% of fatty vacuolation. (G–L) Representative images stained with H&E of liver tissues of aged mice (400×; scale bar, 50 µm); box regions are shown at higher magnification under the original pictures. Values are mean ± SEM, (n = 5–6 per group). ∗P < 0.05 vs Young mice, #P < 0.05 vs aged mice.