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. Author manuscript; available in PMC: 2019 Aug 31.
Published in final edited form as: Cell Metab. 2018 Aug 30;29(1):78–90.e5. doi: 10.1016/j.cmet.2018.08.002

Figure 1. ANT1-Deficiency Induces Transcriptional Changes Associated with Pathological Remodeling of the Heart.

Figure 1.

(A and B) Twenty-five most significantly downregulated (>2-fold, total = 459; A) and upregulated (<0.4-fold, total = 363; B) functionally annotated gene categories in Ant1-null myocardium compared with WT. Searched categories include Gene Ontology, Protein Information Resource, Sequence (Seq) Features, Kyoto Encyclopedia of Genes and Genomes, InterPro protein sequence, and analysis classification. Analysis performed using the Database for Annotation, Visualization and Integrated Discovery (DAVID, v6.7).

(C and D) (C) Fold change in mRNA transcripts from nDNA and (D) mtDNA OXPHOS genes by complex relative to WT (*p < 0.05).

(E) Portion of differentially expressed RNA transcripts from mtDNA. n = 4.

See also Figure S1 and Table S1.