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. Author manuscript; available in PMC: 2019 Aug 31.
Published in final edited form as: Cell Metab. 2018 Aug 30;29(1):78–90.e5. doi: 10.1016/j.cmet.2018.08.002

Figure 7. Effect of Mitochondrial-Nuclear Interaction on Somatic mtDNA Mutation Accumulation.

Figure 7.

(A and B) Long-range amplification of mtDNA(12.7 kb) from each nDNA-mtDNAcombination at 12–15monthsindicating multiple, large-scaledeletions (*p = 0.01; n = 4–6).

(C) Linear regression analysis of the frequency of mtDNA deletions per genome detected by qPCR of the most common deletion hotspot flanking two 15-bp repeats in mtDNA of mice from each strain over 4–25 months of age (p < 0.001; n = 8–14).

(D and E) Correlation between (D) median lifespan or (E) cardiac function and the mtDNA somatic mutation rate, as determined by random mutation capture assay.

See also Figure S7.